Title : Role of Sodium Taurocholate Cotransporting Polypeptide as a New Reporter and Drug-Screening Platform: Implications for Preventing Hepatitis B Virus Infections.

Pub. Date : 2020 Apr

PMID : 31140111






9 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PURPOSE: Sodium taurocholate cotransporting polypeptide (NTCP) is a transmembrane protein responsible for delivering indocyanine green (ICG), an ideal infrared fluorescent dye, from extracellular space into the cytoplasm. Indocyanine Green solute carrier family 10 member 1 Homo sapiens
2 PURPOSE: Sodium taurocholate cotransporting polypeptide (NTCP) is a transmembrane protein responsible for delivering indocyanine green (ICG), an ideal infrared fluorescent dye, from extracellular space into the cytoplasm. Indocyanine Green solute carrier family 10 member 1 Homo sapiens
3 PURPOSE: Sodium taurocholate cotransporting polypeptide (NTCP) is a transmembrane protein responsible for delivering indocyanine green (ICG), an ideal infrared fluorescent dye, from extracellular space into the cytoplasm. Indocyanine Green solute carrier family 10 member 1 Homo sapiens
4 PURPOSE: Sodium taurocholate cotransporting polypeptide (NTCP) is a transmembrane protein responsible for delivering indocyanine green (ICG), an ideal infrared fluorescent dye, from extracellular space into the cytoplasm. Indocyanine Green solute carrier family 10 member 1 Homo sapiens
5 RESULTS: In the reporter study, the ICG signal was higher in NTCP-expressing cells/tumors than in control cells/tumors after ICG treatment. Indocyanine Green solute carrier family 10 member 1 Homo sapiens
6 RESULTS: In the reporter study, the ICG signal was higher in NTCP-expressing cells/tumors than in control cells/tumors after ICG treatment. Indocyanine Green solute carrier family 10 member 1 Homo sapiens
7 In the drug-screening platform study, NTCP-expressing cells had decreased ICG intensity after treatment with NTCP inhibitors and ICG. Indocyanine Green solute carrier family 10 member 1 Homo sapiens
8 In the drug-screening platform study, NTCP-expressing cells had decreased ICG intensity after treatment with NTCP inhibitors and ICG. Indocyanine Green solute carrier family 10 member 1 Homo sapiens
9 In the drug-screening platform study, NTCP-expressing cells had decreased ICG intensity after treatment with NTCP inhibitors and ICG. Indocyanine Green solute carrier family 10 member 1 Homo sapiens