Pub. Date : 2019 Jun
PMID : 31135261
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | These results suggest that PML-RARalpha initiates ATRA-induced transcription through its interaction with MED1. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 2 | Transcriptional activation by PML-RARalpha, an acute promyelocytic leukemia-related oncofusion protein, requires pharmacological concentrations of all-trans retinoic acid (ATRA). | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 3 | Transcriptional activation by PML-RARalpha, an acute promyelocytic leukemia-related oncofusion protein, requires pharmacological concentrations of all-trans retinoic acid (ATRA). | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 4 | Luciferase reporter assays showed that PML-RARalpha induced significant transcription at pharmacological doses (1 muM) of ATRA; however, this was submaximal and equivalent to the level of transcription driven by intact RARalpha at physiological doses (1 nM) of ATRA. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 5 | Luciferase reporter assays showed that PML-RARalpha induced significant transcription at pharmacological doses (1 muM) of ATRA; however, this was submaximal and equivalent to the level of transcription driven by intact RARalpha at physiological doses (1 nM) of ATRA. | Tretinoin | PML nuclear body scaffold | Homo sapiens |