Pub. Date : 2019 Aug
PMID : 31132733
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | L-Fucose ameliorates DSS-induced acute colitis via inhibiting macrophage M1 polarization and inhibiting NLRP3 inflammasome and NF-kB activation. | Fucose | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | In addition, L-fucose can inhibit macrophage M1 polarization, inactivate the NLRP3 inflammasome and reduce the release of TNFalpha, IL1beta, IL6 pro-inflammatory cytokines. | Fucose | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | In vitro studies showed that L-fucose ameliorated cell damage resulting from the administration of LPS with ATP in BMDMs, inhibited NLRP3 inflammasome activation and reduced the release of corresponding pro-inflammatory cytokines. | Fucose | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Overall, our results show that L-fucose can attenuate colitis by inhibiting macrophage M1 polarization, inhibiting NLRP3 inflammasome and NF-kB activation, and down-regulation of pro-inflammatory cytokines. | Fucose | NLR family pyrin domain containing 3 | Homo sapiens |