Pub. Date : 2019 Dec
PMID : 31127617
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of nucleolin on adriamycin resistance via the regulation of B-cell lymphoma 2 expression in Burkitt"s lymphoma cells. | Doxorubicin | nucleolin | Homo sapiens |
| 2 | Adriamycin (ADM) IC50 levels for CA46-NCL-overexpressed (OE), CA46-NCL-OE control (OEC), CA46-NCL-knockdown (KD), and CA46-NCL-KD control (KDC) cells were 0.68 +- 0.06 mug/ml, 0.68 +- 0.06 mug/ml, 0.68 +- 0.06 mug/ml, and 0.30 +- 0.04 mug/ml, respectively. | Doxorubicin | nucleolin | Homo sapiens |
| 3 | Adriamycin (ADM) IC50 levels for CA46-NCL-overexpressed (OE), CA46-NCL-OE control (OEC), CA46-NCL-knockdown (KD), and CA46-NCL-KD control (KDC) cells were 0.68 +- 0.06 mug/ml, 0.68 +- 0.06 mug/ml, 0.68 +- 0.06 mug/ml, and 0.30 +- 0.04 mug/ml, respectively. | Doxorubicin | nucleolin | Homo sapiens |
| 4 | Adriamycin (ADM) IC50 levels for CA46-NCL-overexpressed (OE), CA46-NCL-OE control (OEC), CA46-NCL-knockdown (KD), and CA46-NCL-KD control (KDC) cells were 0.68 +- 0.06 mug/ml, 0.68 +- 0.06 mug/ml, 0.68 +- 0.06 mug/ml, and 0.30 +- 0.04 mug/ml, respectively. | Doxorubicin | nucleolin | Homo sapiens |
| 5 | Adriamycin (ADM) IC50 levels for CA46-NCL-overexpressed (OE), CA46-NCL-OE control (OEC), CA46-NCL-knockdown (KD), and CA46-NCL-KD control (KDC) cells were 0.68 +- 0.06 mug/ml, 0.68 +- 0.06 mug/ml, 0.68 +- 0.06 mug/ml, and 0.30 +- 0.04 mug/ml, respectively. | Doxorubicin | nucleolin | Homo sapiens |
| 6 | Adriamycin (ADM) IC50 levels for CA46-NCL-overexpressed (OE), CA46-NCL-OE control (OEC), CA46-NCL-knockdown (KD), and CA46-NCL-KD control (KDC) cells were 0.68 +- 0.06 mug/ml, 0.68 +- 0.06 mug/ml, 0.68 +- 0.06 mug/ml, and 0.30 +- 0.04 mug/ml, respectively. | Doxorubicin | nucleolin | Homo sapiens |
| 7 | Taken together, these results suggested that NCL could mediate Bcl-2 expression and stability, and thus enhance ADM resistance in CA46 BL cells. | Doxorubicin | nucleolin | Homo sapiens |