Title : Tolerance of DNA Replication Stress Is Promoted by Fumarate Through Modulation of Histone Demethylation and Enhancement of Replicative Intermediate Processing in Saccharomyces cerevisiae.

Pub. Date : 2019 Jul

PMID : 31123043






1 Functional Relationships(s)
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1 Here, we report that Saccharomyces cerevisiae fumarase, Fum1p, acts as a response factor during DNA replication stress, and fumarate enhances survival of yeast lacking Htz1p (H2A.Z in mammals). Fumarates H2A.Z variant histone 1 Homo sapiens