Pub. Date : 1987 Feb
PMID : 3111839
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ketoconazole as a possible universal inhibitor of cytochrome P-450 dependent enzymes: its mode of inhibition. | Ketoconazole | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 2 | Modes of inhibition and binding of ketoconazole, an orally antimycotic agent, to NADPH-cytochrome P-450 dependent enzymes were investigated using subcellular fractions of human and rat testes, human adrenocortical adenoma tissue and rat adrenals and livers. | Ketoconazole | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 3 | Kinetic studies indicated that ketoconazole bound to cytochrome P-450 and not to other components of monooxygenase systems. | Ketoconazole | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 4 | Spectrophotometric studies also revealed direct binding of ketoconazole to cytochrome P-450 component by inducing type II difference spectra in all tissue preparations examined, indicating that ketoconazole is possibly a universal inhibitor of NADPH-cytochrome P-450 dependent monooxygenases which are involved in metabolism of many substances including steroids, toxins, carcinogens and others. | Ketoconazole | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 5 | Spectrophotometric studies also revealed direct binding of ketoconazole to cytochrome P-450 component by inducing type II difference spectra in all tissue preparations examined, indicating that ketoconazole is possibly a universal inhibitor of NADPH-cytochrome P-450 dependent monooxygenases which are involved in metabolism of many substances including steroids, toxins, carcinogens and others. | Ketoconazole | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 6 | Spectrophotometric studies also revealed direct binding of ketoconazole to cytochrome P-450 component by inducing type II difference spectra in all tissue preparations examined, indicating that ketoconazole is possibly a universal inhibitor of NADPH-cytochrome P-450 dependent monooxygenases which are involved in metabolism of many substances including steroids, toxins, carcinogens and others. | Ketoconazole | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 7 | Spectrophotometric studies also revealed direct binding of ketoconazole to cytochrome P-450 component by inducing type II difference spectra in all tissue preparations examined, indicating that ketoconazole is possibly a universal inhibitor of NADPH-cytochrome P-450 dependent monooxygenases which are involved in metabolism of many substances including steroids, toxins, carcinogens and others. | Ketoconazole | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |