Title : Systematic profiling of SH3-mediated Tau-Partner interaction network in Alzheimer's disease by integrating in silico analysis and in vitro assay.

Pub. Date : 2019 Jul

PMID : 31112821






4 Functional Relationships(s)
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1 The aberrant assembly of microtubule-associated protein Tau (tau) into insoluble aggregates is closely related to Alzheimer"s disease (AD), which is elicited from Tau phosphorylation events and regulated by the specific intermolecular recognition between the proline-rich PxxP motifs of Tau and the SH3 domains of its diverse partner proteins/kinases. Proline microtubule associated protein tau Homo sapiens
2 The aberrant assembly of microtubule-associated protein Tau (tau) into insoluble aggregates is closely related to Alzheimer"s disease (AD), which is elicited from Tau phosphorylation events and regulated by the specific intermolecular recognition between the proline-rich PxxP motifs of Tau and the SH3 domains of its diverse partner proteins/kinases. Proline microtubule associated protein tau Homo sapiens
3 The aberrant assembly of microtubule-associated protein Tau (tau) into insoluble aggregates is closely related to Alzheimer"s disease (AD), which is elicited from Tau phosphorylation events and regulated by the specific intermolecular recognition between the proline-rich PxxP motifs of Tau and the SH3 domains of its diverse partner proteins/kinases. Proline microtubule associated protein tau Homo sapiens
4 The aberrant assembly of microtubule-associated protein Tau (tau) into insoluble aggregates is closely related to Alzheimer"s disease (AD), which is elicited from Tau phosphorylation events and regulated by the specific intermolecular recognition between the proline-rich PxxP motifs of Tau and the SH3 domains of its diverse partner proteins/kinases. Proline microtubule associated protein tau Homo sapiens