Title : Micronuclei Formation by Promutagens in Metabolism-Incompetent V79 Cells Interacting With Activation-Proficient Cells in Various Experimental Settings.

Pub. Date : 2020 Feb

PMID : 31112310






2 Functional Relationships(s)
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1 First, 1-methylpyrene, 1-hydroxymethylpyrene, benzo[a]pyrene, and aflatoxin B1 significantly induced micronuclei in V79-hCYP1A2-hSULT1A1, V79-hSULT1A1, V79-hCYP1A1, and V79-hCYP1A2 cells, respectively. Benzo(a)pyrene cytochrome P450 family 1 subfamily A member 1 Homo sapiens
2 Benzo[a]pyrene induced micronuclei in V79-Mz communicating with V79-hCYP1A1 via porous membranes, whereas aflatoxin B1 was inactive in V79-Mz communicating with V79-hCYP1A2. Benzo(a)pyrene cytochrome P450 family 1 subfamily A member 1 Homo sapiens