Title : Adipocyte-specific expression of a retinoic acid receptor α dominant negative form causes glucose intolerance and hepatic steatosis in mice.

Pub. Date : 2019 Jul 5

PMID : 31109648






3 Functional Relationships(s)
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1 Our objective was to characterize the action of ATRA in mature adipocytes of mice by ablating RAR signaling through overexpression of a well-characterized dominant negative RARalpha mutant (RARdn) form specifically in adipocytes. Tretinoin retinoic acid receptor, alpha Mus musculus
2 Our objective was to characterize the action of ATRA in mature adipocytes of mice by ablating RAR signaling through overexpression of a well-characterized dominant negative RARalpha mutant (RARdn) form specifically in adipocytes. Tretinoin retinoic acid receptor, alpha Mus musculus
3 Altered RAR signaling in adipocytes resulted in a significant decrease in ATRA levels in visceral and brown adipose tissues as well as liver tissue. Tretinoin retinoic acid receptor, alpha Mus musculus