Pub. Date : 2019 May 17
PMID : 31101877
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The tamoxifen-responsive conditional Cdh5-CreERT2 is commonly used for endothelial cell specific conditional deletion of loxP-flanked gene sequences. | Tamoxifen | mitogen-activated protein kinase 3 | Mus musculus |
| 2 | To address the role of endothelial cell Shb gene for B16F10 melanoma immune responses, tamoxifen-injected Cdh5-CreERT2/WT and Cdh5-CreERT2/Shbflox/flox mice received subcutaneous tumor cell injections. | Tamoxifen | mitogen-activated protein kinase 3 | Mus musculus |
| 3 | We observed a decrease of tumor myeloid cell Shb mRNA in the tamoxifen treated Cdh5-CreERT2/Shbflox/flox mice, which was not present when the mice had undergone a preceding bone marrow transplantation using wild type bone marrow. | Tamoxifen | mitogen-activated protein kinase 3 | Mus musculus |
| 4 | In the spleen, however, floxing was undetectable two months after tamoxifen treatment, suggesting that Cdh5-CreERT2 is operating in a non-renewable population of hematopoietic cells in this organ. | Tamoxifen | mitogen-activated protein kinase 3 | Mus musculus |