Title : Structural aspects of 4-aminoquinolines as reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase.

Pub. Date : 2019 Aug 1

PMID : 31100281






1 Functional Relationships(s)
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1 Docking studies revealed that the quinoline group within the AChE active site was positioned in the choline binding site, while the C(4)-amino group substituents, depending on their lipophilicity, could establish hydrogen bonds or pi-interactions with residues of the peripheral anionic site. Hydrogen acetylcholinesterase (Cartwright blood group) Homo sapiens