Title : Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.

Pub. Date : 2019 Jun 13

PMID : 31099559






1 Functional Relationships(s)
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1 Aiming to find a novel PDE4 inhibitor acting as an effective, safe, and convenient therapeutic agent, we constructed a library consisting of berberine analogues, and compound 2 with a tetrahydroisoquinoline scaffold was identified as a novel and potent hit. 1,2,3,4-tetrahydroisoquinoline phosphodiesterase 4A Homo sapiens