Title : Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates α-helix formation of the polyQ tract but suppresses its aggregation.

Pub. Date : 2019 May 16

PMID : 31097749






3 Functional Relationships(s)
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1 Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates alpha-helix formation of the polyQ tract but suppresses its aggregation. polyglutamine ataxin 7 Homo sapiens
2 The ARR alpha-helix can initiate and stabilize helical formation of the following polyQ tract, but it may suppress aggregation of the polyQ-expanded Atx7-N both in vitro and in cell. polyglutamine ataxin 7 Homo sapiens
3 Thus, the preceding ARR segment in Atx7-N may influence the dynamic structure and aggregation property of the polyQ tract and even determine the threshold of the pathogenic polyQ lengths. polyglutamine ataxin 7 Homo sapiens