Pub. Date : 2019 May 16
PMID : 31097749
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates alpha-helix formation of the polyQ tract but suppresses its aggregation. | polyglutamine | ataxin 7 | Homo sapiens |
2 | The ARR alpha-helix can initiate and stabilize helical formation of the following polyQ tract, but it may suppress aggregation of the polyQ-expanded Atx7-N both in vitro and in cell. | polyglutamine | ataxin 7 | Homo sapiens |
3 | Thus, the preceding ARR segment in Atx7-N may influence the dynamic structure and aggregation property of the polyQ tract and even determine the threshold of the pathogenic polyQ lengths. | polyglutamine | ataxin 7 | Homo sapiens |