Title : Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells.

Pub. Date : 2019 May 15

PMID : 31092879






2 Functional Relationships(s)
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1 Furthermore, simvastatin impaired the phosphorylation of Akt (Protein Kinase B) mainly at Ser473 and less at Thr308, indicating impaired activity of the mammalian Target of Rapamycin Complex 2 (mTORC2). Simvastatin AKT serine/threonine kinase 1 Homo sapiens
2 In conclusion, simvastatin impaired activation of Akt Ser473 most likely as a consequence of reduced activity of mTORC2. Simvastatin AKT serine/threonine kinase 1 Homo sapiens