Pub. Date : 2019 Jul
PMID : 31087207
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Axonal Protection by Tacrolimus with Inhibition of NFATc1 in TNF-Induced Optic Nerve Degeneration. | Tacrolimus | tumor necrosis factor | Homo sapiens |
| 2 | A significant increase in TNF protein level was observed in optic nerve 14 days after TNF injection and this increase was prevented by tacrolimus. | Tacrolimus | tumor necrosis factor | Homo sapiens |
| 3 | A significant increase in TNF protein level was observed in optic nerve 14 days after TNF injection and this increase was prevented by tacrolimus. | Tacrolimus | tumor necrosis factor | Homo sapiens |
| 4 | Treatment of tacrolimus significantly ameliorated the TNF-mediated axonal loss. | Tacrolimus | tumor necrosis factor | Homo sapiens |
| 5 | These results suggest that tacrolimus is neuroprotective against axon loss in TNF-induced optic neuropathy and that the effect arises from suppression of the CaN/NFATc1 pathway. | Tacrolimus | tumor necrosis factor | Homo sapiens |