Title : Evidence for Anti-Inflammatory Activity of Isoliquiritigenin, 18β Glycyrrhetinic Acid, Ursolic Acid, and the Traditional Chinese Medicine Plants Glycyrrhiza glabra and Eriobotrya japonica, at the Molecular Level.

Pub. Date : 2019 May 10

PMID : 31083310






4 Functional Relationships(s)
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1 LPS upregulated gene expressions of NF-kappaB subunits and of ICAM-1, TNF-alpha, iNOS, and COX-2 within 8 h, which could be decreased by 18beta glycyrrhetinic acid, isoliquiritigenin and ursolic acid similarly to the anti-inflammatory drug dexamethasone. isoliquiritigenin nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 NF-kappaB translocation from cytoplasm to nucleus was observed after LPS stimulation for 2 h and was attenuated by extracts of Glycyrrhiza glabra and Eriobotrya japonica, as well as by 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid. isoliquiritigenin nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
3 Conclusions: 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid inhibited the gene expressions of ICAM-1, TNF-alpha, COX-2, and iNOS, partly through inhibiting NF-kappaB expression and attenuating NF-kappaB nuclear translocation. isoliquiritigenin nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
4 Conclusions: 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid inhibited the gene expressions of ICAM-1, TNF-alpha, COX-2, and iNOS, partly through inhibiting NF-kappaB expression and attenuating NF-kappaB nuclear translocation. isoliquiritigenin nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus