Pub. Date : 1987 Feb
PMID : 3107544
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The inhibition of de novo pyrimidine synthesis prevents the production of deoxyuridine-5-phosphate, the substrate for the synthesis of thymidine-5-phosphate via thymidylate synthase, whereas the inhibition of the choline shunt prevents the production of HCHO groups and glycine, both of which are involved in the synthesis of 5,10-methylenetetrahydrofolate, which is a cofactor of thymidylate synthase. | 2'-deoxyuridylic acid | Thymidylate synthase | Drosophila melanogaster |
2 | The inhibition of de novo pyrimidine synthesis prevents the production of deoxyuridine-5-phosphate, the substrate for the synthesis of thymidine-5-phosphate via thymidylate synthase, whereas the inhibition of the choline shunt prevents the production of HCHO groups and glycine, both of which are involved in the synthesis of 5,10-methylenetetrahydrofolate, which is a cofactor of thymidylate synthase. | 2'-deoxyuridylic acid | Thymidylate synthase | Drosophila melanogaster |