Title : Palmitic Acid-Induced NAD+ Depletion is Associated with the Reduced Function of SIRT1 and Increased Expression of BACE1 in Hippocampal Neurons.

Pub. Date : 2019 Jul

PMID : 31073968






4 Functional Relationships(s)
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1 Palmitic Acid-Induced NAD+ Depletion is Associated with the Reduced Function of SIRT1 and Increased Expression of BACE1 in Hippocampal Neurons. Palmitic Acid sirtuin 1 Homo sapiens
2 A possible molecular mechanism involved in the effects of PA may be through dysfunction of the NAD+ sensor enzyme, SIRT1. Palmitic Acid sirtuin 1 Homo sapiens
3 Therefore, the aim of the present study was to analyze the relationship between the effects of PA metabolism on the function of SIRT1 and the upregulation of BACE1 in cultured hippocampal neurons. Palmitic Acid sirtuin 1 Homo sapiens
4 PA reduced the total amount of NAD+ in neurons that caused an increase in p65 K310 acetylation due to inhibition of SIRT1 activity and low protein content. Palmitic Acid sirtuin 1 Homo sapiens