Pub. Date : 2019 Aug 1
PMID : 31051259
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nitrate (NO3-) contained in food and beverages can transiently increase nitric oxide (NO) availability following a stepwise reduction to nitrite (NO2-) by commensal bacteria in the oral cavity. | Nitrogen Dioxide | NBL1, DAN family BMP antagonist | Homo sapiens |
| 2 | We tested the hypothesis that regular ingestion of dietary NO3- would influence the oral microbiome, the capacity to reduce NO3- to NO2- in saliva, and the vascular responses to an acute dose of NO3-. | Nitrogen Dioxide | NBL1, DAN family BMP antagonist | Homo sapiens |
| 3 | As expected, saliva and plasma NO2- and NO3- were significantly elevated after NO3- supplementation (all P < 0.05) but not placebo. | Nitrogen Dioxide | NBL1, DAN family BMP antagonist | Homo sapiens |
| 4 | Despite these alterations to the oral microbiota, an acute dose of NO3- increased salivary and plasma NO2-, reduced systolic blood pressure and increased the response to flow mediated dilation to a similar extent before and after 7 days of supplementation (P > 0.05). | Nitrogen Dioxide | NBL1, DAN family BMP antagonist | Homo sapiens |