Title : Liposome mediated-CYP1A1 gene silencing nanomedicine prepared using lipid film-coated proliposomes as a potential treatment strategy of lung cancer.

Pub. Date : 2019 Jul 20

PMID : 31051230






3 Functional Relationships(s)
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1 The present work aimed to investigate the role of CYP1A1 gene in PAH-mediated growth and tumor development in vitro and using an in vivo animal model. Polycyclic Aromatic Hydrocarbons cytochrome P450 family 1 subfamily A member 1 Homo sapiens
2 Treatment of PAH-induced human alveolar adenocarcinoma cell line with cationic liposomes carrying CYP1A1 siRNA resulted in down regulation of CYP1A1 mRNA, protein as well as its enzymatic activity, triggering apoptosis and inhibiting multicellular tumor spheroids formation in vitro. Polycyclic Aromatic Hydrocarbons cytochrome P450 family 1 subfamily A member 1 Homo sapiens
3 Treatment of PAH-induced human alveolar adenocarcinoma cell line with cationic liposomes carrying CYP1A1 siRNA resulted in down regulation of CYP1A1 mRNA, protein as well as its enzymatic activity, triggering apoptosis and inhibiting multicellular tumor spheroids formation in vitro. Polycyclic Aromatic Hydrocarbons cytochrome P450 family 1 subfamily A member 1 Homo sapiens