Pub. Date : 2019 Jul
PMID : 31048454
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | B1/G2 cells were also cross-resistant to the ABCB1 substrate doxorubicin, the ABCG2 substrate topotecan, as well as mitoxantrone and the cell cycle checkpoint kinase 1 inhibitor prexasertib, both of which were found to be substrates of both ABCB1 and ABCG2. | Mitoxantrone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | ABCB1 and ABCG2 also functioned additively to transport the common fluorescent substrates mitoxantrone and BODIPY-prazosin, as it was necessary to inhibit both transporters to prevent efflux from B1/G2 cells. | Mitoxantrone | ATP binding cassette subfamily B member 1 | Homo sapiens |