Title : MetAP2 inhibition increases energy expenditure through direct action on brown adipocytes.

Pub. Date : 2019 Jun 14

PMID : 31048375






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Norepinephrine increases energy expenditure in brown adipose tissue by providing fatty acid substrate through lipolysis and by increasing expression of uncoupled protein-1 (UCP1). Norepinephrine uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus
2 Norepinephrine increases energy expenditure in brown adipose tissue by providing fatty acid substrate through lipolysis and by increasing expression of uncoupled protein-1 (UCP1). Norepinephrine uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus
3 Treatment of brown adipocytes with MetAP2 inhibitors enhances norepinephrine-induced lipolysis and energy expenditure, and prolongs the activity of norepinephrine to increase ucp1 gene expression and energy expenditure in norepinephrine-desensitized brown adipocytes. Norepinephrine uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus
4 Treatment of brown adipocytes with MetAP2 inhibitors enhances norepinephrine-induced lipolysis and energy expenditure, and prolongs the activity of norepinephrine to increase ucp1 gene expression and energy expenditure in norepinephrine-desensitized brown adipocytes. Norepinephrine uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus