Title : Copper Chaperone for Superoxide Dismutase Promotes Breast Cancer Cell Proliferation and Migration via ROS-Mediated MAPK/ERK Signaling.

Pub. Date : 2019

PMID : 31024318






2 Functional Relationships(s)
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1 Mechanistically, we found that knockdown of CCS decreases the activity of ERK1/2 mediated by the accumulation of ROS, which leads to the inhibition of cell proliferation and migration. Reactive Oxygen Species mitogen-activated protein kinase 3 Homo sapiens
2 In summary, these results indicated that CCS promotes the growth and migration of breast cancer cells via regulating the ERK1/2 activity mediated by ROS. Reactive Oxygen Species mitogen-activated protein kinase 3 Homo sapiens