Title : Oxalomalate suppresses metastatic melanoma through IDH-targeted stress response to ROS.

Pub. Date : 2019 Apr

PMID : 31020875






1 Functional Relationships(s)
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1 In particular, our study provides the mechanistic foundation that OMA reduces the expression and secretion of MMP-9 through LKB1-mediated PEA3 degradation via the ROS-dependent ATM-Chk2-p53 signalling axis, resulting from inhibition of IDH enzymes. Reactive Oxygen Species tumor protein p53 Homo sapiens