Title : Oxidative cross-linking of calprotectin occurs in vivo, altering its structure and susceptibility to proteolysis.

Pub. Date : 2019 Jun

PMID : 31015146






2 Functional Relationships(s)
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1 Stimulated human neutrophils released calprotectin and subsequently cross-linked it by myeloperoxidase-dependent production of hypochlorous acid. Hypochlorous Acid myeloperoxidase Homo sapiens
2 The myeloperoxidase-derived oxidants hypochlorous acid, taurine chloramine, hypobromous acid, and hypothiocyanous acid, all at 10 muM, cross-linked calprotectin (5 muM) via reversible disulfide bonds. Hypochlorous Acid myeloperoxidase Homo sapiens