Title : Discovery of coumarin Mannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease.

Pub. Date : 2019 Jul 1

PMID : 31005056






1 Functional Relationships(s)
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1 Among the derivatives, 3-(3-(dimethylamino)propanoyl)-7-hydroxy-5-methyl- 2H-chromen-2-one hydrochloride (24) exhibited the most potent and selective hMAO-B inhibitory activity, and anti-inflammatory and neuroprotective effects in the in vitro studies. 3-(3-(dimethylamino)propanoyl)-7-hydroxy-5-methyl- 2h-chromen-2-one hydrochloride monoamine oxidase B Homo sapiens