Title : The anti-angiogenic effect of tryptanthrin is mediated by the inhibition of apelin promoter activity and shortened mRNA half-life in human vascular endothelial cells.

Pub. Date : 2019 May

PMID : 31005035






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Both PD98059 and wortmannin could down-regulate the apelin mRNA expression suggesting the important signaling role of ERK1/2 MAPK and PI3K in the gene expression of apelin. Wortmannin mitogen-activated protein kinase 3 Homo sapiens
2 Both PD98059 and wortmannin could down-regulate the apelin mRNA expression suggesting the important signaling role of ERK1/2 MAPK and PI3K in the gene expression of apelin. Wortmannin mitogen-activated protein kinase 3 Homo sapiens