Title : Antioxidant effect of sildenafil: Potential hepatoprotection via differential expression of mitochondrial proteins in apolipoprotein E knockout mice.

Pub. Date : 2019 Jun

PMID : 31003152






1 Functional Relationships(s)
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1 RESULTS: Compared to the control group, liver cells from apoE-KO presented some typical redox imbalance features: higher levels of intracellular ROS (global oxidative stress ~60%, superoxide anion ~82%, and peroxynitrite/hydroxyl radical ~53%), higher amounts of apoptotic cells (up to ~19%) and higher mitochondrial intensity of catalase (+339%) and transferrin spots (+914%). Superoxides apolipoprotein E Mus musculus