Title : Heparin-LL37 complexes are less cytotoxic for human dental pulp cells and have undiminished antimicrobial and LPS-neutralizing abilities.

Pub. Date : 2019 Sep

PMID : 31002379






4 Functional Relationships(s)
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1 Furthermore, the LPS-neutralizing ability of heparin (5 mug mL-1 )-LL37 (10 mumol L-1 ) complexes, which were found to be less cytotoxic for hDPCs with undiminished antimicrobial ability, was investigated. Heparin L1 cell adhesion molecule Mus musculus
2 Furthermore, the LPS-neutralizing ability of heparin (5 mug mL-1 )-LL37 (10 mumol L-1 ) complexes, which were found to be less cytotoxic for hDPCs with undiminished antimicrobial ability, was investigated. Heparin L1 cell adhesion molecule Mus musculus
3 LL37 (10 mumol L-1 ) binding to heparin within a limited concentration range (2~6 mug mL-1 ) eliminated the cytotoxicity for hDPCs (P < 0.01) whilst exerting potent antimicrobial effects against Streptococcus mutans, Streptococcus sobrinus, Streptococcus salivarius, Aggegatibacter actinomycetemcomitans and Escherichia coli. Heparin L1 cell adhesion molecule Mus musculus
4 LL37 (10 mumol L-1 ) binding to heparin within a limited concentration range (2~6 mug mL-1 ) eliminated the cytotoxicity for hDPCs (P < 0.01) whilst exerting potent antimicrobial effects against Streptococcus mutans, Streptococcus sobrinus, Streptococcus salivarius, Aggegatibacter actinomycetemcomitans and Escherichia coli. Heparin L1 cell adhesion molecule Mus musculus