Title : Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment.

Pub. Date : 2019 May

PMID : 30985942






1 Functional Relationships(s)
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1 The PBPK model predicted that the AUC for mirabegron with itraconazole (a CYP3A4 inhibitor) was 4.12-times that in healthy elderly subjects administered mirabegron alone, and predicted that the proportional change in AUC for desipramine (a CYP2D6 substrate) with mirabegron was greater than that in healthy subjects. Itraconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens