Title : Effects of the Highly COX-2-Selective Analgesic NSAID Etoricoxib on Human Periodontal Ligament Fibroblasts during Compressive Orthodontic Mechanical Strain.

Pub. Date : 2019

PMID : 30983880






3 Functional Relationships(s)
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1 Effects of the Highly COX-2-Selective Analgesic NSAID Etoricoxib on Human Periodontal Ligament Fibroblasts during Compressive Orthodontic Mechanical Strain. Etoricoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 The highly COX-2-selective NSAID etoricoxib has a favorable systemic side effect profile and high analgesic efficacy, particularly for orthodontic pain. Etoricoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 Clinically dosed etoricoxib, that is, a highly selective COX-2 inhibition, did not have substantial effects on hPDL fibroblast-mediated periodontal inflammation, extracellular matrix remodeling, RANK-L/OPG expression, and osteoclastogenesis during simulated orthodontic compressive strain. Etoricoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens