Pub. Date : 2019 Sep
PMID : 30982974
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)-induced epithelial cytokine release through aryl hydrocarbon receptor in asthma. | Benzo(a)pyrene | aryl-hydrocarbon receptor | Mus musculus |
| 2 | The role of aryl hydrocarbon receptor (AhR) signaling in BaP-promoted Der f 1-induced ROS, cytokine production, and allergic inflammation was also investigated. | Benzo(a)pyrene | aryl-hydrocarbon receptor | Mus musculus |
| 3 | Moreover, BaP co-exposure with Der f 1 activated AhR signaling with increased expression of AhR and CYP1A1 and promoted airway epithelial ROS generation and TSLP and IL-33, but not IL-25, expression. | Benzo(a)pyrene | aryl-hydrocarbon receptor | Mus musculus |
| 4 | Moreover, BaP co-exposure with Der f 1 activated AhR signaling with increased expression of AhR and CYP1A1 and promoted airway epithelial ROS generation and TSLP and IL-33, but not IL-25, expression. | Benzo(a)pyrene | aryl-hydrocarbon receptor | Mus musculus |
| 5 | Finally, AhR antagonist CH223191 and NAC inhibited BaP co-exposure with Der f 1-induced lung inflammation. | Benzo(a)pyrene | aryl-hydrocarbon receptor | Mus musculus |
| 6 | CONCLUSIONS: Our findings suggest that BaP facilitates Der f 1-induced epithelial cytokine release through the AhR-ROS axis. | Benzo(a)pyrene | aryl-hydrocarbon receptor | Mus musculus |