Title : [NVP-BKM120 in combination with letrozole inhibit human breast cancer stem cells via PI3K/mTOR pathway].

Pub. Date : 2019 Apr 9

PMID : 30982255






2 Functional Relationships(s)
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1 Result: BKM120 could inhibit BCSC-CYP19 growth by dose-dependence, reduce migration and colony formation of BCSC-CYP19, and also significantly reduced expression of PI3K, Akt1 and S6. NVP-BKM120 AKT serine/threonine kinase 1 Homo sapiens
2 Combined BKM120 and letrozolecaninhibit BCSC-CYP19 growth and proliferation, make BCSC-CYP19 stayed in G0-G1 phase increasing significantly to induce early apoptosis, and down-regulate expression of PI3K, Akt1 and S6. NVP-BKM120 AKT serine/threonine kinase 1 Homo sapiens