Title : PARP Inhibitor Protects Against Chronic Hypoxia/Reoxygenation-Induced Retinal Injury by Regulation of MAPKs, HIF1α, Nrf2, and NFκB.

Pub. Date : 2019 Apr 1

PMID : 30973576






2 Functional Relationships(s)
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1 Here, we analyzed the protective effects of the PARP1 inhibitor olaparib in H/R-induced retina injury and investigated the signaling mechanisms involved. olaparib poly (ADP-ribose) polymerase 1 Rattus norvegicus
2 In addition, olaparib reduced inflammation by NFkappaB dephosphorylation/inactivation, possibly via the PARP1 inhibition-MKP-1 activation-p38 MAPK inhibition pathway. olaparib poly (ADP-ribose) polymerase 1 Rattus norvegicus