Title : Gliclazide Prevents 5-FU-Induced Oral Mucositis by Reducing Oxidative Stress, Inflammation, and P-Selectin Adhesion Molecules.

Pub. Date : 2019

PMID : 30971955






1 Functional Relationships(s)
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1 Treatment with gliclazide 10 mg/kg reduced MPO activity (p < 0.001), MDA levels (p < 0.001) and NFkappaB NLS P50 (p < 0.05) protein levels, resulting in low immunostaining to Cox-2, iNOS (p < 0.05), NFkappaB P65 (p < 0.05), and negative immunoreaction to MMP-2 (p < 0.001). Gliclazide myeloperoxidase Homo sapiens