Title : Metformin prevention of doxorubicin resistance in MCF-7 and MDA-MB-231 involves oxidative stress generation and modulation of cell adaptation genes.

Pub. Date : 2019 Apr 10

PMID : 30971831






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The DOX-res group presented increased thiols and reduced lipoperoxidation, increased levels of nitric oxide, nuclear NF-kB and Nrf2, and reduced nuclear p53 labelling. Doxorubicin tumor protein p53 Homo sapiens
2 The Met-DOX group was more sensitive to DOX-induced OS, presented lower levels of nitric oxide, nuclear NF-kB and Nrf2, and increased nuclear p53. Doxorubicin tumor protein p53 Homo sapiens