Pub. Date : 2019 Apr 10
PMID : 30971286
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Microglial NLRP3 inflammasome activation mediates IL-1beta release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model. | Nitroglycerin | NLR family, pyrin domain containing 3 | Mus musculus |
| 2 | RESULTS: Repeated NTG administration induced acute and chronic mechanical hyperalgesia and increased expression of NLRP3 and IL-1beta. | Nitroglycerin | NLR family, pyrin domain containing 3 | Mus musculus |
| 3 | Blockade of NLRP3 or IL-1beta reduced NTG-induced hyperalgesia, and this effect was accompanied by a significant inhibition of the NTG-induced increase in p-ERK, c-Fos and CGRP levels in the TNC. | Nitroglycerin | NLR family, pyrin domain containing 3 | Mus musculus |
| 4 | Blockade of NLRP3 or IL-1beta reduced NTG-induced hyperalgesia, and this effect was accompanied by a significant inhibition of the NTG-induced increase in p-ERK, c-Fos and CGRP levels in the TNC. | Nitroglycerin | NLR family, pyrin domain containing 3 | Mus musculus |