Pub. Date : 2019 Apr 7
PMID : 30959948
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Association between Polymorphisms of OCT1 and Metabolic Response to Metformin in Women with Polycystic Ovary Syndrome. | Metformin | solute carrier family 22 member 1 | Homo sapiens |
| 2 | Organic cation transporter (OCT) 1 and 2 have been reported to mediate metformin transport in the liver and kidney, respectively. | Metformin | solute carrier family 22 member 1 | Homo sapiens |
| 3 | In this study, we investigated the association between the polymorphisms of OCT1 and OCT2 and the treatment effectiveness of metformin in PCOS patients. | Metformin | solute carrier family 22 member 1 | Homo sapiens |
| 4 | However, PCOS patients with the G allele of OCT1 rs683369 and/or with the A allele of OCT1 rs628031 had increased insulin sensitivity compared to those with wild-type genotype after receiving metformin treatment. | Metformin | solute carrier family 22 member 1 | Homo sapiens |
| 5 | Moreover, the interactions of metformin*SNP were significant in both OCT1 rs683369 (p < 0.001) and rs628031 (p = 0.001) during the treatment period. | Metformin | solute carrier family 22 member 1 | Homo sapiens |
| 6 | Taken together, genetic polymorphisms of OCT1 contributed to different metformin treatment responses, and further study is needed to establish personalized treatment programs using a pharmacogenomic algorithm approach in PCOS patients. | Metformin | solute carrier family 22 member 1 | Homo sapiens |