Title : Decreased pulmonary drug metabolism in mice treated with the PCB metabolite 4-methylsulphonyl-2,2',5,5'-tetrachlorobiphenyl.

Pub. Date : 1986 Sep

PMID : 3095957






1 Functional Relationships(s)
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1 After treatment of mice with 4-MeSO2-TCB (100 mg/kg), the pulmonary N-demethylation of aminopyrine in vitro was significantly decreased, while hepatic N-demethylation was concomitantly increased, as compared to tissue from control mice. Aminopyrine pyruvate kinase M1/2 Homo sapiens