Title : Oxidation of human plasma fibronectin by inflammatory oxidants perturbs endothelial cell function.

Pub. Date : 2019 May 20

PMID : 30959171






3 Functional Relationships(s)
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1 The cause(s) of this dysfunction are unresolved, but accumulating evidence suggests that oxidants arising from chronic low-grade inflammation are contributory agents, with increasing data implicating myeloperoxidase (MPO, released by activated leukocytes), and the oxidants it generates (e.g. HOCl and HOSCN). Hypochlorous Acid myeloperoxidase Homo sapiens
2 The cause(s) of this dysfunction are unresolved, but accumulating evidence suggests that oxidants arising from chronic low-grade inflammation are contributory agents, with increasing data implicating myeloperoxidase (MPO, released by activated leukocytes), and the oxidants it generates (e.g. HOCl and HOSCN). Hypochlorous Acid myeloperoxidase Homo sapiens
3 Modifications were detected on HCAEC-derived ECM pre-treated with HOCl, but not HOSCN, with a loss of antibody recognition of the CBF, HBF and extra-domain A. Co-localization of epitopes arising from MPO-generated HOCl and cell-derived FN was detected in human atherosclerotic lesions. Hypochlorous Acid myeloperoxidase Homo sapiens