Title : Anti-inflammatory activities of Canarium subulatum Guillaumin methanol extract operate by targeting Src and Syk in the NF-κB pathway.

Pub. Date : 2019 Jun 28

PMID : 30951845






3 Functional Relationships(s)
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1 Moreover, we found that Cs-ME reduced the phosphorylation of NF-kappaB upstream signaling molecules including IkappaBalpha, IKKalpha/beta, Src, and Syk in LPS-stimulated macrophage-like RAW264.7 cells. cs-me Rous sarcoma oncogene Mus musculus
2 The results of Western blot and CETSA confirmed that Src and Syk are anti-inflammatory targets of Cs-ME. cs-me Rous sarcoma oncogene Mus musculus
3 CONCLUSIONS: Cs-ME exhibits anti-inflammatory effects in vitro and in vivo by targeting Src and Syk in the NF-kappaB signaling pathway. cs-me Rous sarcoma oncogene Mus musculus