Title : Dynamic and structural differences between heme oxygenase-1 and -2 are due to differences in their C-terminal regions.

Pub. Date : 2019 May 17

PMID : 30944174






3 Functional Relationships(s)
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1 Here, using hydrogen-deuterium exchange MS, size-exclusion chromatography, and sedimentation velocity, we investigated how these divergent regions impact the dynamics and structure of the apo and heme-bound forms of HO1 and HO2. Heme heme oxygenase 1 Homo sapiens
2 Our results reveal that heme binding to the catalytic cores of HO1 and HO2 causes similar dynamic and structural changes in regions (proximal, distal, and A6 helices) within and linked to the heme pocket. Heme heme oxygenase 1 Homo sapiens
3 Our results reveal that heme binding to the catalytic cores of HO1 and HO2 causes similar dynamic and structural changes in regions (proximal, distal, and A6 helices) within and linked to the heme pocket. Heme heme oxygenase 1 Homo sapiens