Pub. Date : 2019 May
PMID : 30942616
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Effect of Angiotensin-Converting Enzyme Gene Polymorphisms on the Clinical Efficacy of Perindopril Prescribed for Acute Myocardial Infarction in Chinese Han Patients. | Perindopril | angiotensin I converting enzyme | Homo sapiens |
| 2 | Objective: Perindopril is an angiotensin-converting enzyme (ACE) inhibitor that is commonly used in the treatment of Chinese Han patients with acute myocardial infarction (AMI). | Perindopril | angiotensin I converting enzyme | Homo sapiens |
| 3 | Objective: Perindopril is an angiotensin-converting enzyme (ACE) inhibitor that is commonly used in the treatment of Chinese Han patients with acute myocardial infarction (AMI). | Perindopril | angiotensin I converting enzyme | Homo sapiens |
| 4 | However, there have been few studies on whether polymorphisms of the ACE gene affect the efficacy of perindopril or the prognosis of AMI patients. | Perindopril | angiotensin I converting enzyme | Homo sapiens |
| 5 | The purpose of this study was to analyze the relationship among the ACE rs121912703 (C>T), rs767880620 (C>A), and rs397514689 (C>T) gene polymorphisms and the prognosis of AMI patients and the clinical efficacy of perindopril in the treatment of AMI. | Perindopril | angiotensin I converting enzyme | Homo sapiens |
| 6 | Methods: The ACE genotypes at the rs121912703, rs767880620, and rs397514689 loci in 225 AMI patients treated with perindopril were determined by polymerase chain reaction/Sanger sequencing. | Perindopril | angiotensin I converting enzyme | Homo sapiens |
| 7 | Results: After administration of perindopril, improved ventricular remodeling in AMI patients with wild-type ACE was better than in patients with the ACE rs121912703, rs767880620, and rs397514689 minor variant alleles. | Perindopril | angiotensin I converting enzyme | Homo sapiens |
| 8 | Conclusion: Mutations at the ACE rs121912703, rs767880620, and rs397514689 loci affect the efficacy of perindopril on ventricular remodeling and hemodynamics in Chinese Han AMI patients. | Perindopril | angiotensin I converting enzyme | Homo sapiens |