Title : Proteomics profiling of arginine methylation defines PRMT5 substrate specificity.

Pub. Date : 2019 Apr 2

PMID : 30940768






1 Functional Relationships(s)
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1 Through in vitro methylation assays, we validated a set of PRMT5 targets identified by mass spectrometry and provided previously unknown mechanistic insights into the preference of the enzyme to methylate arginine sandwiched between two neighboring glycines (a Gly-Arg-Gly, or "GRG," sequence). Glycine protein arginine methyltransferase 5 Homo sapiens