Title : Repeated treatments with the D1 dopamine receptor agonist SKF-38393 modulate cell viability via sustained ERK-Bad-Bax activation in dopaminergic neuronal cells.

Pub. Date : 2019 Jul 23

PMID : 30930179






3 Functional Relationships(s)
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1 SKF-38393 administration for 8 weeks induced phosphorylation of sustained ERK1/2 and Bad (Bcl-2-associated death promoter) at Ser155 (BadSer155), and augmented Bax (Bcl-2-associated X protein) expression. 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine mitogen activated protein kinase 3 Rattus norvegicus
2 SKF-38393 (20 and 50 muM) induced sustained ERK1/2 and BadSer155 phosphorylation as well as caspase-3 activation. 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine mitogen activated protein kinase 3 Rattus norvegicus
3 At a non-toxic level (5 muM), SKF-38393 produced only transient ERK1/2 and BadSer112 phosphorylation. 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine mitogen activated protein kinase 3 Rattus norvegicus