Pub. Date : 2019 Jul 5
PMID : 30928633
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 8-Acetonyldihydronitidine inhibits the proliferation of human colorectal cancer cells via activation of p53. | 8-acetonyldihydronitidine | tumor protein p53 | Homo sapiens |
| 2 | Mechanistically, 8-AHN induced p53 expression and enhanced transcriptional activity, subsequently elevating the expression of p53 target genes, including p21, FAS, and BAX, and then increased the level of activated caspase-3 and decreased the level of cyclin B and cyclin A. | 8-acetonyldihydronitidine | tumor protein p53 | Homo sapiens |
| 3 | Mechanistically, 8-AHN induced p53 expression and enhanced transcriptional activity, subsequently elevating the expression of p53 target genes, including p21, FAS, and BAX, and then increased the level of activated caspase-3 and decreased the level of cyclin B and cyclin A. | 8-acetonyldihydronitidine | tumor protein p53 | Homo sapiens |
| 4 | Moreover, pifithrin-alpha, the p53 inhibitor, markedly reversed the above responses induced by 8-AHN, and small interfering RNA-mediated knockdown of TP53 also significantly decreased 8-AHN-induced cell apoptosis. | 8-acetonyldihydronitidine | tumor protein p53 | Homo sapiens |
| 5 | Moreover, pifithrin-alpha, the p53 inhibitor, markedly reversed the above responses induced by 8-AHN, and small interfering RNA-mediated knockdown of TP53 also significantly decreased 8-AHN-induced cell apoptosis. | 8-acetonyldihydronitidine | tumor protein p53 | Homo sapiens |
| 6 | In summary, 8-AHN displays an antitumor effect through cell cycle arrest and apoptosis in colorectal cells via activating p53, which suggests that 8-AHN, exerted a therapeutic potential against colorectal cancer cells, and may be regarded as an effective lead compound. | 8-acetonyldihydronitidine | tumor protein p53 | Homo sapiens |
| 7 | In summary, 8-AHN displays an antitumor effect through cell cycle arrest and apoptosis in colorectal cells via activating p53, which suggests that 8-AHN, exerted a therapeutic potential against colorectal cancer cells, and may be regarded as an effective lead compound. | 8-acetonyldihydronitidine | tumor protein p53 | Homo sapiens |