Title : Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia and Statin Intolerance.

Pub. Date : 2019 Apr 2

PMID : 30922146






1 Functional Relationships(s)
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1 Bempedoic acid, a prodrug that is activated by a hepatic enzyme not present in skeletal muscle, inhibits ATP -citrate lyase, an enzyme upstream of beta-hydroxy beta-methylglutaryl-coenzyme A reductase in the cholesterol biosynthesis pathway. 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid ATP citrate lyase Homo sapiens