Pub. Date : 2019 Mar 27
PMID : 30919109
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To determine the mechanism(s) by which cortisol induces CYP3A activity, HepaRG cells were pre-incubated in dexamethasone-free medium and then incubated for 72 h with cortisol (798 nM). | Hydrocortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | To determine the mechanism(s) by which cortisol induces CYP3A activity, HepaRG cells were pre-incubated in dexamethasone-free medium and then incubated for 72 h with cortisol (798 nM). | Hydrocortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | CYP3A4, and not CYP3A5, was found to be the dominant contributor to total CYP3A activity in control- and cortisol-treated HepaRG cells. | Hydrocortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | CYP3A4, and not CYP3A5, was found to be the dominant contributor to total CYP3A activity in control- and cortisol-treated HepaRG cells. | Hydrocortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | Cortisol-mediated CYP3A4 induction in HepaRG cells was primarily mediated by GR-dependent PXR induction pathway and to a smaller extent via a PXR-independent pathway. | Hydrocortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | These data indicate that PXR plays a central role in cortisol-mediated induction of CYP3A activity during pregnancy and suggests that other enzymes and transporters, such as CYP2B6 and P-glycoprotein, may also be induced during pregnancy via the same mechanism(s). | Hydrocortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |