Title : Structure-Activity Relationships of Rationally Designed Ritonavir Analogues: Impact of Side-Group Stereochemistry, Headgroup Spacing, and Backbone Composition on the Interaction with CYP3A4.

Pub. Date : 2019 Apr 16

PMID : 30912932






2 Functional Relationships(s)
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1 Structure-Activity Relationships of Rationally Designed Ritonavir Analogues: Impact of Side-Group Stereochemistry, Headgroup Spacing, and Backbone Composition on the Interaction with CYP3A4. Ritonavir cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 In a continuing effort to identify structural attributes required for strong binding and potent inhibition of human drug-metabolizing CYP3A4, we designed ten ritonavir-like analogues differing in the side-group stereochemistry, backbone atomic composition, and headgroup spacing. Ritonavir cytochrome P450 family 3 subfamily A member 4 Homo sapiens