Title : The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling Network.

Pub. Date : 2019

PMID : 30911355






2 Functional Relationships(s)
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1 Multiple signaling pathways including ERK, PI3K-Akt, and NF-kappaB, which are essential for onset and development of cancer, can be activated by intracellularly sustained high levels of H2O2 provided by elevated activity and expression of copper/zinc superoxide dismutase (SOD1) that catalyzes the dismutation of O2 - into H2O2. Hydrogen Peroxide nuclear factor kappa B subunit 1 Homo sapiens
2 Multiple signaling pathways including ERK, PI3K-Akt, and NF-kappaB, which are essential for onset and development of cancer, can be activated by intracellularly sustained high levels of H2O2 provided by elevated activity and expression of copper/zinc superoxide dismutase (SOD1) that catalyzes the dismutation of O2 - into H2O2. Hydrogen Peroxide nuclear factor kappa B subunit 1 Homo sapiens